IT2033 BIOINFORMATICS SYLLABUS R-2008

IT2033 BIOINFORMATICS L T P C
3 0 0 3

UNIT I 9
Introduction to molecular biology – the genetic material – gene structure – protein structure – chemical bonds – molecular biology tools – genomic information content

UNIT II 9
Data searches – simple alignments – gaps – scoring matrices – dynamic programming – global and local alignments – database searches – multiple sequence alignments Patterns for substitutions – estimating substitution numbers – evolutionary rates – molecular clocks – evolution in organelles

UNIT III 9
Phylogenetics – history and advantages – phylogenetic trees – distance matrix methods – maximum likelihood approaches – multiple sequence alignments – Parsimony – ancestral sequences – strategies for faster searches – consensus trees – tree confidence – comparison of phylogenetic methods – molecular phylogenies

UNIT IV 9
Genomics – prokaryotic genomes: prokaryotic gene structure – GC content - gene density – eukaryotic genomes: gene structure – open reading frames – GC content – gene expression – transposition – repeated elements – gene density

UNIT V 9
Amino acids – polypeptide composition – secondary structure – tertiary and quaternary structure – algorithms for modeling protein folding – structure prediction – predicting RNA secondary structures
Proteomics – protein classification – experimental techniques – inhibitors and drug design – ligand screening – NMR structures – empirical methods and prediction techniques – post-translational modification prediction

TOTAL: 45 PERIODS

TEXT BOOK:
1. D. E. Krane and M. L. Raymer, “Fundamental concepts of Bioinformatics”, Pearson Education, 200UNIT III

1. Arthur M. Lesk, “Introduction to Bioinformatics”, Second Edition, Oxford University Press, 2005.
2. T. K. Attwood, D. J. Parry-Smith, and S. Phukan, “Introduction to Bioinformatics”, Pearson Education, 1999.
3. Vittal R. Srinivas, “Bioinformatics – A Modern Approach”, Prentice-Hall of India Pvt. Ltd., 2005.